Gq-dependent signaling in adipose tissue - focus on brown adipocytes

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Prof. Dr. Alexander Pfeifer

Sigmund-Freund-Str. 25

53127 Bonn

Team members

N.N.

Publications

Kuschak M, Namasivayam V, Rafehi M, Voss JH, Garg J, Schlegel JG, Abdelrahman A, Kehraus S, Reher R, Küppers J, Sylvester K, Hinz S, Matthey M, Wenzel D, Fleischmann BK, Pfeifer A, Inoue A, Gütschow M, König GM, Müller CE. (2020) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors. Br J Pharmacol. doi: 10.1111/bph.14960. Epub 2020 Feb 11. PMID: 31881095; PMCID: PMC7070167.

Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E (2019) Direct targeting of Gαq and Gα11 oncoproteins in cancer cells Sci. Signal. doi: 10.1126/scisignal.aau5948 

Klepac K, Kilic A, Gnad T, Brown LM, Herrmann B, Wildermann A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA and Pfeifer A (2016); The Gq signalling pathway inhibits brown and beige adipose tissue, Nat commun, 7, 10895, doi: 10.1038/ncomms10895

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